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If you have diabetes
and are overweight,you could have silent
liver disease too.

Learn about fatty liver disease and NASH,

and see if you may qualify for a clinical trial.

Liver-collage-V2

Learn about fatty liver disease and NASH,

and see if you may qualify for a clinical trial.

Do I Have Fatty Liver Disease/NASH?

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Nonalcoholic steatohepatitis (NASH) is a severe form of fatty liver disease that often has no symptoms, but can cause significant damage to your liver if not diagnosed early. If you struggle with your weight, have high blood pressure or high cholesterol, you may also have fatty liver disease.

NASH means you have excess fat in your liver that leads to swelling and damage of the liver cells. As the disease progresses, scarring or fibrosis, of the liver tissue appears. Eventually it can lead to cirrhosis (advanced, late-stage scarring) or liver cancer. NASH is not related to alcohol use.1

While there are no medications approved for NASH, doctors recommend a healthy diet and exercise.2 A clinical research trial may also be an option.

About the Clinical Trial

The MK-3655-001 Clinical Trial is evaluating the safety and effectiveness of MK-3655, an investigational medication for people with NASH. This trial will test MK-3655 compared to placebo. A placebo looks like the study medication but contains no active ingredient. The clinical trial will last up to 16 months and include up to 16 study visits.

See if you're eligible

*The information you provide is completely confidential.

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Who Can Participate?

You may be eligible to participate if you:*

  • Are a male or postmenopausal female, 18 to 80 years of age [in Japan: age 20 to 80]
  • Have NASH confirmed by a liver biopsy

  • Do not have type 2 diabetes OR have type 2 diabetes that is well controlled by diet or a stable dose of diabetes medication

  • Have had a stable weight for at least 3 months

 

*There may be additional requirements to participate. The study doctor can provide you with more information.

Why Participate?

If you qualify and decide to participate:

  • Your liver and your overall health will be monitored closely by an experienced study team

  • You will receive the investigational medication and study-related doctor visits at no charge

  • The information gathered may help advance medical knowledge about NASH and may improve patient care in the future

  • Participation is voluntary, and you are free to withdraw from the study at any time. Your privacy will be maintained throughout the study

 

Additional potential risks and benefits of participation will be fully described to you by your study team.

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See if you're eligible

*The information you provide is completely confidential.

Frequently Asked Questions

This section will help answer some important questions you may have.

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About NASH

  • How do I know if I'm at risk for NASH?

  • How is NASH diagnosed?

  • How common is NASH?

About the MK-3655 Study

  • Who is the sponsor of this study?

  • Why is this clinical research study being conducted?

  • How do I decide if this study is right for me?

  • Whom can I contact if I have more questions?

  • What is a placebo?

Privacy, Stopping Participation, Costs, and Permission

  • What happens to my personal information?

  • Can I withdraw from the study after I have started?

  • Do I have to pay to participate?

  • Will I be paid for taking part/reimbursed for travel?

  • Does my doctor have to give permission?

About Clinical Research

  • What is a clinical research study?

  • Who oversees clinical research studies?

  • Who can participate in a clinical research study?

  • What is an investigational medication?

See if you're eligible

*The information you provide is completely confidential.

References

1 Brochure for patients who have been diagnosed with NAFLD or NASH. Global Liver Institute. https://static1.squarespace.com/static/53bafd3ce4b0ae714af7153f/t/5cc8b8158165f5f89b2c49d6/1556658197576/nash-fact-sheets-treatment-4print.pdf. Accessed September 5, 2020.

2 Treatment for NAFLD and NASH. National Institute of Diabetes and Digestive and Kidney Diseases website. https://www.niddk.nih.gov/health-information/liver-disease/nafld-nash/treatment. Accessed September 21.

3 Symptoms & Causes of NAFLD & NASH. National Institute of Diabetes and Digestive and Kidney Diseases website. https://www.niddk.nih.gov/health-information/liver-disease/nafldnash/symptoms-causes. Accessed September 21, 2020.

4 Continuum Clinical, February 2019 national survey, adults 18+ (n=1014); Aided awareness.

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